Instacast Master Runes.

 1.3.6 Update - Master runes are losing their 2s cast times and actually becoming really insta-cast. No reason to stop using the keybind though as it still reduces mouseclicking. Should be able to have even higher uptime on your master runes now.

Just a quick tip of the day, as I don't see Runepriests taking advantage of their Master Runes very often:

Bind your Master Rune to the keyboard!

 

  I found these spells to be extremely irritating when I started my RP: having to recast every 30s; TARGET IS OUT OF RANGE; and the amount of mousemovement required. Now that it is bound to X I can double tap the button to cast it and I aim it with my second hand. This is a lot more time efficient than moving your cursor to the bar, clicking, moving it to where you want, and clicking again. When you get a dreaded out of range you will be glad you don't have to repeat that process again.